Hydrochloric Acid → HCID 178519262, compound

HRID 893942Notes

Reaction equation

HRID 893942 reaction equation
C([O:3][C:4]([C:6]1[CH:18]=[C:17]2[N:8]([C:9](=[S:19])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1)=O)C.[BH4-].[Li+].Cl>O>[OH:3][CH2:4][C:6]1[CH:18]=[C:17]2[N:8]([C:9](=[S:19])[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=32)[N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4148881Lithium borohydrideHCID 178468473HCID 178468473, compound

Product 1

HCID 178519262HCID 178519262, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.519 g (0.0019 mole) of 5,6-dihydro-5-thioxopyrazolo-[1,5-c]quinazoline-2-carboxylic acid ethyl ester is suspended in 10 ml distilled tetrahydrofuran and treated with 0.1 g (0.004 mole) of 85% lithium borohydride at room temperature. After 20 hours of stirring, the reaction mixture is cooled to 0°, 4.5 ml of 1N hydrochloric acid is added and stirring is continued for 30 minutes. 25 ml of water is added and the product is filtered off after 10 minutes and dried.

Workup

  1. distillationdistilled tetrahydrofuran
  2. temperaturethe reaction mixture is cooled to 0°
  3. stirringstirring
  4. waitis continued for 30 minutes
  5. filtrationthe product is filtered off after 10 minutes
  6. customdried

Sources & evidence

ORD record
ord-5e26b6d9850f4c5bb21db8c6dc7182ec
Source dataset
uspto-grants-1981_08
Patent number
US04282226

Reaction notes

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