Hydrochloric Acid → HCID 21162245, compound

HRID 893983Notes

Reaction equation

HRID 893983 reaction equation
[ClH:1].[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8][S:9][CH2:10][CH2:11][NH:12][C:13]([NH:15][CH2:16][CH2:17][S:18][CH2:19][C:20]1[N:21]=[CH:22][NH:23][C:24]=1[CH3:25])=[S:14].[CH3:26]O>>[ClH:1].[ClH:1].[ClH:1].[CH3:26][S:14][C:13](=[N:12][CH2:11][CH2:10][S:9][CH2:8][C:4]1[N:5]=[CH:6][NH:7][C:3]=1[CH3:2])[NH:15][CH2:16][CH2:17][S:18][CH2:19][C:20]1[N:21]=[CH:22][NH:23][C:24]=1[CH3:25]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15566017HCID 15566017, compound

Product 1

HCID 21162245HCID 21162245, compound

Procedure

Dry hydrogen chloride was passed into a solution of N,N'-bis-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea (7.7 g) in methanol at 80° for 5 hours. Concentration and re-evaporation with isopropyl alcohol afforded S-methyl-N,N'-bis-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-isothiourea trihydrochloride (9.0 g), m.p. 212°-215° (isopropyl alcohol).

Workup

  1. concentrationConcentration and re-evaporation with isopropyl alcohol

Sources & evidence

ORD record
ord-d451bc61bcae4a03a875cbdc80667935
Source dataset
uspto-grants-1981_08
Patent number
US04282234

Reaction notes

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