反应详情

Pyrrole (2.0 g., 30 mmoles) was dissolved in 20 ml. of ether. Benzenesulfenyl chloride (4.5 g., 30 mmoles) was added dropwise at such a rate that the purple color of the reagent was discharged. A slightly exothermic reaction was noted. After addition was complete (10 minutes), the reaction was evaporated to an oil (5.7 g.). The oil was chromatographed on approximately 180 ml. of silica gel, eluted with ethyl acetate-1/hexane-7. Middle fractions, evaporated to dryness, afforded 2-phenylthiopyrrole (300 mg.).

1. customA slightly exothermic reaction
2. additionAfter addition
3. custom(10 minutes)
4. customthe reaction was evaporated to an oil (5.7 g.)
5. customThe oil was chromatographed on approximately 180 ml
6. washof silica gel, eluted with ethyl acetate-1/hexane-7
7. customMiddle fractions, evaporated to dryness