Diethyl Ether → 2-(4-Phenylbenzoylmethyl)imidazo [3,4-a]pyridinium Bromide

Participants

Reaction Steps

Imidazo[3,4-a]pyridine (7.1 g., 60 mmoles), dissolved in 150 ml. of ether, was mixed with p-phenylphenacyl bromide dissolved in 100 ml. of tetrahydrofuran and stirred for 4 hours at room temperature. A first crop of crystalline 2-(4-phenylbenzoylmethyl)imidazo[3,4-a]pyridinium bromide [7.8 g., m.p. 258°-260° C. (dec.)] was recovered by filtration. After standing four days at room temperature, a second crop of crystallized product [9.5 g., m.p. 262°-264° C. (dec.)] was recovered from the filtrate.

Provenance & Evidence