反应详情

Imidazo[3,4-a]pyridine (7.1 g., 60 mmoles), dissolved in 150 ml. of ether, was mixed with p-phenylphenacyl bromide dissolved in 100 ml. of tetrahydrofuran and stirred for 4 hours at room temperature. A first crop of crystalline 2-(4-phenylbenzoylmethyl)imidazo[3,4-a]pyridinium bromide [7.8 g., m.p. 258°-260° C. (dec.)] was recovered by filtration. After standing four days at room temperature, a second crop of crystallized product [9.5 g., m.p. 262°-264° C. (dec.)] was recovered from the filtrate.

1. dissolutiondissolved in 100 ml
2. filtrationA first crop of crystalline 2-(4-phenylbenzoylmethyl)imidazo[3,4-a]pyridinium bromide [7.8 g., m.p. 258°-260° C. (dec.)] was recovered by filtration
3. customa second crop of crystallized product [9.5 g., m.p. 262°-264° C. (dec.)] was recovered from the filtrate