N-(3-Aminopropyl)morpholine → HCID 20532969, compound

HRID 894107Notes

Reaction equation

HRID 894107 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.O1CCN(CCN[S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])CC1>>[O:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:1][S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 20513743HCID 20513743, compound

Product 1

HCID 20532969HCID 20532969, compound

Procedure

In the manner described above, substituting N-(3-aminopropyl)morpholine (41.35 grams; 0.286 mole) for the N-(2-aminoethyl)morpholine and recrystallizing the crude product from methylcyclohexane, N-(3-morpholinopropyl)trifluoromethanesulfonamide is obtained, m.p. 95°-97° C.

Workup

  1. customrecrystallizing the crude product from methylcyclohexane

Sources & evidence

ORD record
ord-c24c35fe43564a80b3b5bd2b06a9e110
Source dataset
uspto-grants-1981_08
Patent number
US04282357

Reaction notes

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