Sodium Methoxide → HCID 178434373, compound

Participants

Reaction Steps

An intramolecular ring closure is then performed to produce a pyrazolo[4,3-d]pyrimidine nucleus. This can be done by introducing 4-formylamino-3-methylpyrazole-5-carboxamide into refluxing dimethylformamide containing a catalytic amount of sodium methoxide to produce 7-hydroxy-3-methylpyrazolo[4,3-d]pyrimidine in high yield and excellent purity.

Provenance & Evidence