Sodium Methoxide → HCID 178434373, compound

HRID 894109Notes

Reaction equation

HRID 894109 reaction equation
[CH:1]([NH:3][C:4]1[C:5]([CH3:12])=[N:6][NH:7][C:8]=1[C:9]([NH2:11])=[O:10])=O.C[O-].[Na+]>CN(C)C=O>[OH:10][C:9]1[C:8]2[NH:7][N:6]=[C:5]([CH3:12])[C:4]=2[N:3]=[CH:1][N:11]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 178434625HCID 178434625, compound

Product 1

HCID 178434373HCID 178434373, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

An intramolecular ring closure is then performed to produce a pyrazolo[4,3-d]pyrimidine nucleus. This can be done by introducing 4-formylamino-3-methylpyrazole-5-carboxamide into refluxing dimethylformamide containing a catalytic amount of sodium methoxide to produce 7-hydroxy-3-methylpyrazolo[4,3-d]pyrimidine in high yield and excellent purity.

Sources & evidence

ORD record
ord-d1a445db5ec649cdbae5fa5d1462af78
Source dataset
uspto-grants-1981_08
Patent number
US04282361

Reaction notes

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