Pentylamine → HCID 178446271, compound

HRID 894119Notes

Reaction equation

HRID 894119 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH2:3][CH2:4][CH3:5].Cl[C:8]1[C:9]2[NH:16][N:15]=[C:14]([CH3:17])[C:10]=2[N:11]=[CH:12][N:13]=1>O>[CH3:17][C:14]1[C:10]2[N:11]=[CH:12][N:13]=[C:8]([NH:6][CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:9]=2[NH:16][N:15]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 178434331HCID 178434331, compound

Product 1

HCID 178446271HCID 178446271, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

When n-pentylamine (7 g) was added to 7-chloro-3-methylpyrazolo[4,3-d]pyrimidine (6.13 g, 36 mmol), an exothermic reaction took place and the mixture heated itself to boiling. The cooled reaction mixture was triturarted with water (100 ml). The crude product crystallized and was filtered, washed with water and air-dried to give a quantitative crude yield of slightly yellow crystals. Recrystallization from ether and treatment with charcoal afforded the product, yield 5.0 g (63%), m.p. 157.5°-158.5°. An additional 1.24 g was recovered from the mother liquor as the maleinate. Total yield, 73.6%.

Workup

  1. customan exothermic reaction
  2. temperaturethe mixture heated itself
  3. customThe cooled reaction mixture
  4. customThe crude product crystallized
  5. filtrationwas filtered
  6. washwashed with water
  7. customair-dried
  8. customto give a quantitative crude yield of slightly yellow crystals
  9. customRecrystallization from ether and treatment with charcoal
  10. customafforded the product, yield 5.0 g (63%), m.p. 157.5°-158.5°
  11. customAn additional 1.24 g was recovered from the mother liquor as the maleinate

Sources & evidence

ORD record
ord-97875f6fddfe4d789cf1d354d1d9273e
Source dataset
uspto-grants-1981_08
Patent number
US04282361

Reaction notes

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