Pentylamine → HCID 178446271, compound

Participants

Reaction Steps

When n-pentylamine (7 g) was added to 7-chloro-3-methylpyrazolo[4,3-d]pyrimidine (6.13 g, 36 mmol), an exothermic reaction took place and the mixture heated itself to boiling. The cooled reaction mixture was triturarted with water (100 ml). The crude product crystallized and was filtered, washed with water and air-dried to give a quantitative crude yield of slightly yellow crystals. Recrystallization from ether and treatment with charcoal afforded the product, yield 5.0 g (63%), m.p. 157.5°-158.5°. An additional 1.24 g was recovered from the mother liquor as the maleinate. Total yield, 73.6%.

Provenance & Evidence