反应详情

A mixture of the product of Step A (4.0 g; 15.0 mmoles) and propargylamine (6.88 g; 125 mmoles) in methanol (20 ml) was stirred and heated to reflux temperature under a positive pressure of nitrogen for 20 hours. The reaction mixture was evaporated under reduced pressure and the product recrystallized from acetonitrile to give the title compound; mp 124.5°-130.5° C. (remelted at 128°-131.5° C.).

1. temperatureheated
2. temperatureto reflux temperature under a positive pressure of nitrogen for 20 hours
3. customThe reaction mixture was evaporated under reduced pressure
4. customthe product recrystallized from acetonitrile