反应详情

Reflux a mixture of 7.43 gm. (0.0316 mole) of 6,11-dihydro-11-oxodibenz[b,e]oxepin-9-carbonitrile, 130 ml. of acetic acid, 13 ml. of water and 13 ml. of concentrated hydrochloric acid for 156 hours. Cool the reaction mixture, separate the solids by filtration and dry (yield 6.20 gm., m.p. 264°-269° C.). Recrystallize from acetic acid to obtain the title product (m.p. 270.5°-271.5° C.).

1. temperatureReflux
2. additiona mixture of 7.43 gm
3. temperatureCool the reaction mixture
4. customseparate the solids
5. filtrationby filtration
6. customdry (yield 6.20 gm., m.p. 264°-269° C.)
7. customRecrystallize from acetic acid