反应详情

Stir a mixture of 1.0 gm of 6-methylphthalide and 0.64 gm of sodium phenolate at a temperature of 200°-210° C. for 1 hour. Cool and dissolve the reaction mixture in water. Acidify with 5% hydrochloric acid and extract with ether. Evaporate to dryness and chromatograph the residue over silica gel eluting with chloroform/methanol (50:1). Evaporate the eluate to dryness and crystallize the residue from ethyl acetate/benzene to obtain the title product.

1. temperatureCool
2. extractionextract with ether
3. customEvaporate to dryness and chromatograph the residue over silica gel eluting with chloroform/methanol (50:1)
4. customEvaporate the eluate to dryness
5. customcrystallize the residue from ethyl acetate/benzene