Hydrochloric Acid → HCID 178514953, compound

HRID 894198Notes

Reaction equation

HRID 894198 reaction equation
[NH:1]1[C:5]([C:6]2[CH:21]=[CH:20][C:9]3[O:10][CH2:11][C:12]4[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=4[C:14](=[O:15])[C:8]=3[CH:7]=2)=[N:4][N:3]=[N:2]1.C(O)C.[BH4-].[Na+].Cl>O>[NH:4]1[C:5]([C:6]2[CH:21]=[CH:20][C:9]3[O:10][CH2:11][C:12]4[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=4[CH:14]([OH:15])[C:8]=3[CH:7]=2)=[N:1][N:2]=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 4311764Sodium borohydrideHCID 178514952HCID 178514952, compound

Product 1

HCID 178514953HCID 178514953, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Suspend 1 gm. of 2-(1H-tetrazol-5-yl)-6,11-dihydro-11-oxodibenz[b,e]oxepin in 100 cc. of absolute ethanol and add excess sodium borohydride in portions. Dilute the resulting solution with water and acidify with aqueous conc. hydrochloric acid. Separate the solids by filtration. Crystallize from ethyl acetate to obtain the title product (m.p. 335° C.).

Workup

  1. customSeparate the solids
  2. filtrationby filtration
  3. customCrystallize from ethyl acetate

Sources & evidence

ORD record
ord-4d9cec16e13d419bbdb9908a4b11e24b
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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