Hydrochloric Acid → HCID 12929147, compound

HRID 894206Notes

Reaction equation

HRID 894206 reaction equation
[CH:1]1[C:11]2[CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:16]([O:18]C)=[O:17].[OH-].[Na+].Cl>C(O)C.O>[CH:1]1[C:11]2[CH2:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH2:7][O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:16]([OH:18])=[O:17]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21162718HCID 21162718, compound

Product 1

HCID 12929147HCID 12929147, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Dissolve 1.4 gm of the ester of Step A in 15 ml of ethanol and add 15 ml of 20% aqueous sodium hydroxide. Warm gently on a steam bath until complete solution is obtained. Strip to dryness and dissolve in water. Acidify with concentrated hydrochloric acid and separate the precipitate by filtration. Crystallize from methanol to obtain the title product (m.p. 240°-244° C.)

Workup

  1. temperatureWarm gently on a steam bath until complete solution
  2. customis obtained
  3. customseparate the precipitate
  4. filtrationby filtration
  5. customCrystallize from methanol

Sources & evidence

ORD record
ord-14b362e00c6d4b87a5e10fd1f119700b
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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