Methanol → HCID 14724117, compound

HRID 894207Notes

Reaction equation

HRID 894207 reaction equation
C[C:2](C)([O-:4])C.[K+].CO.Cl[CH:10]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH2:14][O:13][C:12]2[CH:21]=[CH:22][C:23]([C:25]([O:27][CH3:28])=[O:26])=[CH:24][C:11]1=2>CN(C)C=O.O>[CH3:2][O:4][CH:10]1[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[CH2:14][O:13][C:12]2[CH:21]=[CH:22][C:23]([C:25]([O:27][CH3:28])=[O:26])=[CH:24][C:11]1=2

Participants

6

Reactant 3

HCID 887MethanolHCID 10446851HCID 10446851, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 14724117HCID 14724117, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent2×

Procedure

Mix 0.415 gm of potassium tert-butoxide, 5 ml of methanol and 5 ml of dimethylformamide and add the mixture to a solution of 1.07 gm of methyl 6,11-dihydro-11-chlorodibenz[b,e]oxepin-2-carboxylate in 40 ml of dimethylformamide. Stir at room temperature for 3 days. Dilute with water and extract with ether. Evaporate to dryness and chromatograph over silica gel with benzene as the eluting solvent to obtain the title product.

Workup

  1. extractionextract with ether
  2. customEvaporate to dryness and chromatograph over silica gel with benzene as the eluting solvent

Sources & evidence

ORD record
ord-868c5e9586fe4bcb973605cfdde217e1
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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