Hydrochloric Acid → HCID 12929149, compound

Participants

Reaction Conditions

Reaction Steps

Dissolve 3.1 gm of the ester of Step A in a mixture of 60 ml of methanol and 60 ml of tetrahydrofuran. Add 60 ml of 5% aqueous potassium hydroxide and heat the mixture at 70° C. under a nitrogen atmosphere for 5 hours. Pour the mixture onto ice and acidify to pH 5 with concentrated hydrochloric acid. Separate the solids by filtration. Wash with cold water and dry at 60° C. under vacuum for 2 hours to obtain the title product (m.p. 244°-255° C. dec.).

Provenance & Evidence