Hydrochloric Acid → HCID 12929149, compound

HRID 894212Notes

Reaction equation

HRID 894212 reaction equation
[N:1]1([CH:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[CH2:10][O:9][C:8]3[CH:17]=[CH:18][C:19]([C:21]([O:23]C)=[O:22])=[CH:20][C:7]2=3)[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[K+].Cl>CO.O1CCCC1>[N:1]1([CH:6]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[CH2:10][O:9][C:8]3[CH:17]=[CH:18][C:19]([C:21]([OH:23])=[O:22])=[CH:20][C:7]2=3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 21162743HCID 21162743, compound

Product 1

HCID 12929149HCID 12929149, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

Dissolve 3.1 gm of the ester of Step A in a mixture of 60 ml of methanol and 60 ml of tetrahydrofuran. Add 60 ml of 5% aqueous potassium hydroxide and heat the mixture at 70° C. under a nitrogen atmosphere for 5 hours. Pour the mixture onto ice and acidify to pH 5 with concentrated hydrochloric acid. Separate the solids by filtration. Wash with cold water and dry at 60° C. under vacuum for 2 hours to obtain the title product (m.p. 244°-255° C. dec.).

Workup

  1. additionPour the mixture onto ice
  2. customSeparate the solids
  3. filtrationby filtration
  4. washWash with cold water
  5. customdry at 60° C. under vacuum for 2 hours

Sources & evidence

ORD record
ord-3e060f4b6f884f29978798cb5b1eaf1a
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

Loading…