Formamide → HCID 21162715, compound

HRID 894213Notes

Reaction equation

HRID 894213 reaction equation
Cl[CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:16][C:3]1=2.[CH:21]([NH2:23])=[O:22]>O>[CH:21]([NH:23][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19][CH3:20])=[O:18])=[CH:16][C:3]1=2)=[O:22]

Participants

4

Reactant 2

HCID 713FormamideHCID 10446851HCID 10446851, compound

Product 1

HCID 21162715HCID 21162715, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
110 °C

Procedure

Add 2.35 gm. of methyl 6,11-dihydro-11-chlorodibenz[b,e]oxepin-2-carboxylate to 20 ml. of formamide. Stir and heat the mixture at 110° C. for 3 hours. Cool to room temperature, dilute with water and separate the solids by filtration to obtain the title product (Yield 2.18 gm., 90%).

Workup

  1. additionAdd 2.35 gm
  2. temperatureCool to room temperature
  3. customseparate the solids
  4. filtrationby filtration

Sources & evidence

ORD record
ord-68785163ecec4292942d528e6d61d2e1
Source dataset
uspto-grants-1981_08
Patent number
US04282365

Reaction notes

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