HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6,11-Dihydro-11-ethylidenedibenz[b,e]oxepin-2-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Cyano-6,11-dihydro-11-ethylidenedibenz[b,e]oxepin | HCID 53673425 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6,11-Dihydro-11-ethylidenedibenz[b,e]oxepin-2-carboxylic Acid | HCID 54539695 | — |
Reaction Steps
Reflux a mixture of 2.8 gm of the nitrile of Step A, 50 ml of acetic acid, 5 ml of water and 5 ml of concentrated hydrochloric acid for 140 hours. Cool the reaction mixture, separate the solids by filtration and dry. Recrystallize from toluene to obtain the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04282365 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-e65d07c7de3d4a0dbf28170e3b422d46 |
| Source note | uspto-grants-1981_08 |