反应详情

Reflux a mixture of 2.8 gm of the nitrile of Step A, 50 ml of acetic acid, 5 ml of water and 5 ml of concentrated hydrochloric acid for 140 hours. Cool the reaction mixture, separate the solids by filtration and dry. Recrystallize from toluene to obtain the title product.

1. temperatureReflux
2. temperatureCool the reaction mixture
3. customseparate the solids
4. filtrationby filtration
5. customdry
6. customRecrystallize from toluene