反应详情

By the procedure of Example 13, m-fluorothiophenol (3.0 g., 23.4 mmoles) was reacted with cuprous oxide (1.67 g., 11.7 mmoles) in 30 ml. of dimethylformamide and then reacted further with 5-bromofuran-3-carboxylic acid in 30 ml. of dimethylformamide. Isolation of crude solids (920 mg.) was according to Example 9. Recrystallization from methanol/water, which included decolorization with activated carbon, gave purified 5-(3-fluorophenylthio)furan-3-carboxylic acid (500 mg., m.p. 101°-103° C., m/e 238).

1. customRecrystallization from methanol/water, which
2. customgave
3. custompurified 5-(3-fluorophenylthio)furan-3-carboxylic acid (500 mg., m.p. 101°-103° C., m/e 238)