反应详情

In 30 ml of methanol was dissolved 4.09 g of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and then 15 ml of a methanol solution of 2.88 g of sulfamide was added to the solution under refluxing. After refluxing for about 3 hours, the solvent was distilled off under reduced pressure and the residue was purified by a silica gel column chromatography using a mixture of chloroform and methanol (20:1→10:1) as the developing solvent to provide 3,26 g of N-sulfamoyl-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine. The product shows the following physical chemical properties:

1. temperatureunder refluxing
2. temperatureAfter refluxing for about 3 hours
3. distillationthe solvent was distilled off under reduced pressure
4. customthe residue was purified by a silica gel column chromatography
5. additiona mixture of chloroform and methanol (20:1→10:1) as the developing solvent