反应详情

In 10 ml of ethanol were dissolved 1 g of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and 0.69 g p-aminobenzenesulfonamide and after causing reaction for 48 hours at room temperature, the solvent was distilled off under reduced pressure. Then, the residue formed was purified by a silica gel column chromatography using a mixture of chloroform and methanol (20:1→10:1) to provide 1.2 g N-(p-aminobenzenesulfonyl)-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine as an amorphous solid. The product shows the following physicochemical properties.

1. customreaction for 48 hours at room temperature
2. distillationthe solvent was distilled off under reduced pressure
3. customThen, the residue formed
4. customwas purified by a silica gel column chromatography
5. additiona mixture of chloroform and methanol (20:1→10:1)