Sulfanilamide → HCID 178512699, compound

Participants

Reaction Steps

In 10 ml of ethanol were dissolved 1 g of methyl 3-[(2-guanidinothiazol-4-yl)methylthio]propionimidate and 0.69 g p-aminobenzenesulfonamide and after causing reaction for 48 hours at room temperature, the solvent was distilled off under reduced pressure. Then, the residue formed was purified by a silica gel column chromatography using a mixture of chloroform and methanol (20:1→10:1) to provide 1.2 g N-(p-aminobenzenesulfonyl)-3-[(2-guanidinothiazol-4-yl)methylthio]propionamidine as an amorphous solid. The product shows the following physicochemical properties.

Provenance & Evidence