Hydrogen Peroxide → HCID 86737932, compound

HRID 894316Notes

Reaction equation

HRID 894316 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([C:14]2[CH:18]=[CH:17][S:16][CH:15]=2)=[C:7]2[CH2:12][CH2:11][N:10]([CH3:13])[CH2:9][CH2:8]2)=[CH:2]1.[OH:19]O>CO>[S:1]1[CH:5]=[CH:4][C:3]([C:6]([C:14]2[CH:18]=[CH:17][S:16][CH:15]=2)=[C:7]2[CH2:12][CH2:11][N+:10]([O-:19])([CH3:13])[CH2:9][CH2:8]2)=[CH:2]1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 20575146HCID 20575146, compound

Product 1

HCID 86737932HCID 86737932, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.5 grams (0.02 mole) of 4-(di-3-thienyl-methylene)-N-methyl-piperidine were dissolved in 50 ml of methanol and treated with 7.2 grams of 30% hydrogen peroxide dropwise with ice cooling and left at room temperature for 8 days. Excess hydrogen peroxide was destroyed by the addition of Pt-carbon. After the filtering and removal of the solvent at room temperature the amineoxide was crystallized in ethyl acetate. M.P. 92°-96° C.; Yield: 77%.

Workup

  1. customExcess hydrogen peroxide was destroyed by the addition of Pt-carbon
  2. customAfter the filtering and removal of the solvent at room temperature the amineoxide
  3. customwas crystallized in ethyl acetate

Sources & evidence

ORD record
ord-af5c452b8abd46b5a9f7ca0f03baeb09
Source dataset
uspto-grants-1981_08
Patent number
US04283405

Reaction notes

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