反应详情

5,6-Dichloro-1-ethyl-2-methylbenzimidazole (22.9 g, 0.10 moles), 3-chloropropyltrimethylsilane (15.0 g, 0.10 moles), and sodium iodide (15.0 g, 0.10 moles) were suspended in acetonitrile (200 ml) and with stirring the mixture was refluxed for 17 hours. It was filtered while hot to remove NaCl and the filtrate treated with ether (300 ml). Solid which precipitated was filtered off, washed with ether and dried. Yield 11.3 g (24%) mp 213°-5°. Additional crops were obtained by concentrating the filtrates and adding more ether. The mp of each crop was lower and less exact than the previous crop but all crops contained at least some product.

1. temperaturewas refluxed for 17 hours
2. filtrationIt was filtered while hot
3. customto remove NaCl
4. additionthe filtrate treated with ether (300 ml)
5. customSolid which precipitated
6. filtrationwas filtered off
7. washwashed with ether
8. customdried
9. customAdditional crops were obtained
10. concentrationby concentrating the filtrates
11. additionadding more ether