Sulfuric Acid → 5-(1,1-Dimethylethyl)-N-methyl-1,3,4-thiadiazol-2-amine

HRID 894386Notes

Reaction equation

HRID 894386 reaction equation
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[C:7](O)(=O)[C:8]([CH3:11])([CH3:10])[CH3:9].S(=O)(=O)(O)O>>[C:8]([C:11]1[S:6][C:3]([NH:2][CH3:1])=[N:4][N:5]=1)([CH3:10])([CH3:9])[CH3:7]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 6417Pivalic acidHCID 2723853N-Methylhydrazinecarbothioamide

Product 1

HCID 1708665-(1,1-Dimethylethyl)-N-methyl-1,3,4-thiadiazol-2-amine

Procedure

feeding the contents of said first and second vessels concomitantly into a third vessel containing a heel, i.e., a reacted mixture having been formed previously by reacting 4-methyl-3-thiosemicarbazide with a solution of pivalic acid in the presence of a solution containing concentrated polyphosphoric acid and concentrated sulfuric acid to form 5-t-butyl-2-methylamino-1,3,4-thiadiazole in situ;

Workup

  1. additioncontaining a heel, i.e.
  2. customa reacted mixture having been formed previously

Sources & evidence

ORD record
ord-e1755bb8906b4bb2a5c15a866f30efc2
Source dataset
uspto-grants-1981_08
Patent number
US04283543

Reaction notes

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