Thionyl Chloride → 2-Bromophenylacetyl chloride

HRID 894396Notes

Reaction equation

HRID 894396 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.S(Cl)([Cl:14])=O>C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([Cl:14])=[O:11]

Participants

4

Reactant 2

HCID 24386Thionyl Chloride2×HCID 877542-Bromophenylacetic acid

Product 1

HCID 41383862-Bromophenylacetyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

For 3 hours, 21 g (0.098 mole) of o-bromophenylacetic acid was refluxed in 100 ml of anhydrous benzene and 23.5 g (0.198 mole) of thionyl chloride. After completion of the reaction, benzene and unreacted thionyl chloride were removed by distillation under reduced pressure so that unreacted thionyl chloride was removed as completely as possible.

Workup

  1. customwere removed by distillation under reduced pressure so that unreacted thionyl chloride
  2. customwas removed as completely as possible

Sources & evidence

ORD record
ord-e032945e75a74b5995973d270c9a0711
Source dataset
uspto-grants-1981_08
Patent number
US04283532

Reaction notes

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