Methanol → HCID 12952916, compound

HRID 894406Notes

Reaction equation

HRID 894406 reaction equation
[CH:1]([CH:3]([CH2:10][CH3:11])[CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7])=[O:2].[C:12](=[O:15])([O-])[O-].[K+].[K+].[CH3:18]O>S(=O)(=O)(O)O>[CH3:18][O:2][CH:1]([O:15][CH3:12])[CH:3]([CH2:10][CH3:11])[CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7]

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 10866598methyl 4-formylhexanoate

Product 1

HCID 12952916HCID 12952916, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

To a solution containing anhydrous methanol (70 ml) and concentrated sulfuric acid (3 drops) was added methyl 4-formylhexanoate (10.2 g, 64.5 mmol). The solution was stirred at room temperature for 24 hours then solid potassium carbonate was added to neutralize the acid. Most of the solvent was evaporated under vacuum, then water (100 ml) was added and the solution extracted twice with hexane (50 ml) then twice with ether. The organic phases were combined and dried over anhydrous magnesium sulfate.

Workup

  1. customMost of the solvent was evaporated under vacuum
  2. additionwater (100 ml) was added
  3. extractionthe solution extracted twice with hexane (50 ml)
  4. dry with materialdried over anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-8a390bf85f5f4505be530e5f14d22106
Source dataset
uspto-grants-1981_08
Patent number
US04283536

Reaction notes

Loading…