反应详情

A mixture of 0.5 g. (1.31 mmols.) of 4-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-2-butanone, 360 mg. of solid sodium bicarbonate, 100 mg. of 10% palladium-on-carbon and 10 ml. of ethanol is stirred under one atmosphere of hydrogen pressure for one hour. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and the filtrate evaporated to an oil. The oil is purified via column chromatography on 100 g. of silica gel eluted with 50% ether-cyclohexane to yield 247 mg. (93%) of the title compound as an oil.

1. additionA mixture of 0.5 g
2. filtrationThe reaction mixture is filtered through diatomaceous earth with ethyl acetate
3. customthe filtrate evaporated to an oil
4. customThe oil is purified via column chromatography on 100 g
5. washof silica gel eluted with 50% ether-cyclohexane
6. customto yield 247 mg