Hydrochloric Acid → HCID 70555377, compound

HRID 894462Notes

Reaction equation

HRID 894462 reaction equation
[OH:1][C@H:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]2[CH2:13][CH2:14][N:15]([CH3:17])[CH2:16][C@@H:5]2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[ClH:22].[CH3:23]O>>[ClH:22].[CH3:23][O:1][C@H:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:6]2[CH2:13][CH2:14][N:15]([CH3:17])[CH2:16][C@@H:5]2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887Methanol2×HCID 54162446HCID 54162446, compound

Product 1

HCID 70555377HCID 70555377, compound

Procedure

1 g cis-10-hydroxy-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine is suspended in 25 ml methanol, after which 2 ml of a saturated solution of HCl in methanol is added and the mixture is boiled for about 1 hour with exclusion of moisture. The solution is evaporated to dryness under vacuum and the residue is crystallized from methanol. Yield 300 mg. Melting point of the HCl salt: 247°-251° C.; melting point free base 182°-184° C.

Workup

  1. customThe solution is evaporated to dryness under vacuum
  2. customthe residue is crystallized from methanol
  3. custom247°-251° C.
  4. custompoint free base 182°-184° C.

Sources & evidence

ORD record
ord-d9e6c80465e64511ad24fe8a86778fc8
Source dataset
uspto-grants-1981_08
Patent number
US04284559

Reaction notes

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