反应详情

To a solution of 5-aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (0.519 g.) in pyridine (5 ml.) was added methanesulfonyl chloride (0.28 ml.) under ice-cooling, followed by stirring. The reaction mixture was poured into cooled dilute hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to remove the solvent. The residue was recrystallized from ethanol. By the above procedure there was obtained 5-methylsulfonylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one as colorless needles melting at 152°-154° C.

1. temperaturecooling
2. additionThe reaction mixture was poured
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. customdried
6. concentrationconcentrated
7. customto remove the solvent
8. customThe residue was recrystallized from ethanol