Potassium Hydroxide → HCID 12926018, compound

HRID 894622Notes

Reaction equation

HRID 894622 reaction equation
C([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:11]3([CH2:13][CH2:12]3)[O:10][C:9]=2[CH:16]=1)(=O)C.[OH-].[K+]>CO>[NH2:4][C:5]1[CH:6]=[CH:7][C:8]2[C:14](=[O:15])[C:11]3([CH2:13][CH2:12]3)[O:10][C:9]=2[CH:16]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 12783859HCID 12783859, compound

Product 1

HCID 12926018HCID 12926018, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1.09 g. of 6-acetylaminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one in 50 ml. of methanol was added 0.8 g. of potassium hydroxide, and the mixture was refluxed for 0.5 hour. The solvent was evaporated off under reduced pressure. To the residue was added water, and the precipitating crystals were collected by filtration, washed with water and dried. The crystals were recrystallized from methanol to obtain 6-aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one as colorless prisms melting at 188°-189° C.

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. additionTo the residue was added water
  3. filtrationthe precipitating crystals were collected by filtration
  4. washwashed with water
  5. customdried
  6. customThe crystals were recrystallized from methanol

Sources & evidence

ORD record
ord-e5a8400be145407aae414a761284ea26
Source dataset
uspto-grants-1981_08
Patent number
US04284644

Reaction notes

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