Methyl Isocyanate → HCID 12926035, compound

HRID 894630Notes

Reaction equation

HRID 894630 reaction equation
[NH2:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][C:7]3([C:10](=[O:11])[C:4]=2[CH:3]=1)[CH2:9][CH2:8]3.[CH3:14][N:15]=[C:16]=[O:17]>O1CCCC1>[CH3:14][NH:15][C:16](=[O:17])[NH:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][C:7]3([C:10](=[O:11])[C:4]=2[CH:3]=1)[CH2:9][CH2:8]3

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 12925991HCID 12925991, compound

Product 1

HCID 12926035HCID 12926035, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-Aminospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (1.75 g.) and methyl isocyanate (1 ml.) were stirred in tetrahydrofuran for 2 hours at room temperature. The solvent was evaporated off under reduced pressure, and the residue was recrystallized from ethanol to give yellow prisms of 5-methylureidospiro[benzo[b]furan-2(3H),1'-cyclopropane]-3-one (1.06 g.).

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-6b7f8a5a3a354a0f89b647e5ab53fa89
Source dataset
uspto-grants-1981_08
Patent number
US04284644

Reaction notes

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