HCID 70072613, compound → HCID 21328040, compound

HRID 894671Notes

Reaction equation

HRID 894671 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH:34](OCC)[O:35]CC)=[C:5]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N+:26]([O-:28])=[O:27])[C:7]=1[C:8]([O:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:9]>CC(C)=O.Cl>[CH3:1][C:2]1[NH:3][C:4]([CH:34]=[O:35])=[C:5]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N+:26]([O-:28])=[O:27])[C:7]=1[C:8]([O:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:9]

Participants

4

Reactant 1

HCID 70072613HCID 70072613, compound

Product 1

HCID 21328040HCID 21328040, compoundYield 102.4%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

Starting from a mixture of 2-phenoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-diethoxymethyl-1,4-dihydropyridine-3-carboxylate (1.24 g) in acetone (12 ml) and 6 N hydrochloric acid (1.2 ml) was obtained an oil (1.1 g) of 2-phenoxyethyl 2-methyl-4-(2-nitrophenyl)-5-ethoxycarbonyl-6-formyl-1,4-dihydropyridine-3-carboxylate, in a substantially similar manner to that of Example 2-6).

Sources & evidence

ORD record
ord-e893f3bba337484e8ef4a0564598dfdd
Source dataset
uspto-grants-1981_08
Patent number
US04284634

Reaction notes

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