O-((2-methylthiazol-4-yl)methyl)hydroxylamine → HCID 53718792, compound

HRID 894761Notes

Reaction equation

HRID 894761 reaction equation
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=O)[C:10]([OH:12])=[O:11])[N:8]=1)=[O:2].[CH3:14][C:15]1[S:16][CH:17]=[C:18]([CH2:20][O:21][NH2:22])[N:19]=1>CO>[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:22][O:21][CH2:20][C:18]2[N:19]=[C:15]([CH3:14])[S:16][CH:17]=2)[C:10]([OH:12])=[O:11])[N:8]=1)=[O:2]

Participants

4

Reactant 2

HCID 425143O-((2-methylthiazol-4-yl)methyl)hydroxylamineHCID 13116693(2-Formamido-1,3-thiazol-4-yl)(oxo)acetic acid

Product 1

HCID 53718792HCID 53718792, compoundYield 65.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2-(2-formamidothiazol-4-yl)glyoxylic acid (1.10 g.) and 2-methylthiazol-4-ylmethoxyamine (0.99 g.) in methanol (17 ml.) was stirred at room temperature for 3 hours. The precipitates were collected by filtration and washed with methanol to give 2-(2-formamidothiazol-4-yl)-2-(2-methylthiazol-4-ylmethoxyimino)-acetic acid (syn isomer, 1.17 g.).

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with methanol

Sources & evidence

ORD record
ord-42bdba8debd3498097020434757c8e68
Source dataset
uspto-grants-1981_08
Patent number
US04284631

Reaction notes

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