Methanol → HCID 54271022, compound

HRID 894781Notes

Reaction equation

HRID 894781 reaction equation
N[C:2]1([C:7](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:8]([O:10]CC)=[O:9])[CH2:6][S:5][CH:4]=[N:3]1.[OH-].[Na+].C[N:26]1C=CN=C1.CO>O1CCCC1>[NH2:26][C:4]1[S:5][CH:6]=[C:2]([C:7](=[N:13][O:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[C:8]([OH:10])=[O:9])[N:3]=1

Participants

6

Reactant 4

HCID 887MethanolHCID 13901-MethylimidazoleHCID 14798Sodium HydroxideHCID 73684194HCID 73684194, compound

Product 1

HCID 54271022HCID 54271022, compoundYield 261.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethyl 2-(4-aminothiazol-4-yl)-2-(4-chlorobenzyloxyimino)acetate (syn isomer, 21.15 g.), 1 N sodium hydroxide aqueous solution (94 ml.), 1-methylimidazole (1.02 g.), methanol (220 ml.) and tetrahydrofuran (150 ml.) were treated in a similar manner to that of Example P-(4) to give 2-(2-aminothiazol-4-yl)-2-(4-chlorobenzyloxyimino)acetic acid (syn isomer, 10.13 g.).

Sources & evidence

ORD record
ord-662843f3d73442419ba8a4fc13a64c65
Source dataset
uspto-grants-1981_08
Patent number
US04284631

Reaction notes

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