HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromotrimethylsilane → (6R,7R)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(phosphonocarbamoyloxymethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | N-trimethylsilylurethane | HCID 11355656 | — |
| Reactant | (6R,7R)-3-(dimethoxyphosphorylcarbamoyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 88764320 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (6R,7R)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(phosphonocarbamoyloxymethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 88760882 | — |
Reaction Steps
Bromotrimethylsilane (0.61 g), in dichloromethane (3 ml) was added (at 0° under nitrogen) to a stirred solution of (6R,7R)-3-dimethoxyphosphorylcarbamoyloxymethyl-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acid (0.53 g) and trimethylsilylurethane (0.965 g) in dry dichloromethane (5 ml). After 1.75 hours no starting cephalosporin remained as indicated by t.l.c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04284766 |
| Source dataset | uspto-grants-1981_08 |
| ORD ID | ord-1ba7a33139484ec0a62fe7bfe6eca9cc |
| Source note | uspto-grants-1981_08 |