反应详情

A solution of 2.0 g. of 4-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-2-butanone in 15 ml. of pyridine is treated at 10° C. with 10 ml. acetic anhydride and the mixture stirred for 18 hours under nitrogen. It is then poured onto ice/water and acidified with dilute hydrochloric acid. The acidified mixture is extracted with ethyl acetate (2×100 ml.), the extracts combined, washed with brine and dried (MgSO4). Evaporation under reduced pressure affords the title product as an oil.

1. additionIt is then poured onto ice/water
2. extractionThe acidified mixture is extracted with ethyl acetate (2×100 ml.)
3. washwashed with brine
4. dry with materialdried (MgSO4)
5. customEvaporation under reduced pressure