Phosphorus trichloride → HCID 20498424, compound

HRID 894962Notes

Reaction equation

C(=O)([O-])[O:2][CH:3]([CH:8]1[CH:10]([C:11]([O:13][CH3:14])=[O:12])[C:9]1([CH3:16])[CH3:15])[C:4]([Cl:7])([Cl:6])[Cl:5].[Na+].[P:20](Cl)([Cl:22])[Cl:21]>>[P:20]([Cl:22])([Cl:21])[O:2][CH:3]([CH:8]1[CH:10]([C:11]([O:13][CH3:14])=[O:12])[C:9]1([CH3:16])[CH3:15])[C:4]([Cl:7])([Cl:6])[Cl:5]

Participants

Reactant 2

HCID 24387Phosphorus trichloride

HCID 70525463HCID 70525463, compound2×

Product 1

HCID 20498424HCID 20498424, compound

Conditions

Temperature: 40 °C

Procedure

A 10-ml flask was charged with sodium 2,2,2-trichloro-1-(2,2-dimethyl-3-methoxycarbonylcyclopropyl)ethyl carbonate (compound 4, 0.73 mmol) and phosphorus trichloride (0.80 mmol) and stirred at 40° C. for 45 min. Then, the excess of phosphorus trichloride was removed at sub-atmospheric pressure. The conversion of compound 4 was at least 92%, with a selectivity to the title compound of at least 79%.

Workup

customThen, the excess of phosphorus trichloride was removed at sub-atmospheric pressure

Sources & evidence

ORD record: ord-b7cca7f7b9ce446088601a9889bb1a9e
Source dataset: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04285882

Reaction notes

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