2-(Diisopropylamino)ethyl chloride → 1-(Diisopropylamino-ethoxyimino)cyclododecane

HRID 894992Notizen

Reaktionsgleichung

[H-].[Na+].[C:3]1(=[N:15][OH:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[CH:17]([N:20]([CH:24]([CH3:26])[CH3:25])[CH2:21][CH2:22]Cl)([CH3:19])[CH3:18].C(O)(=O)/C=C/C([O-])=O>>[CH:17]([N:20]([CH2:21][CH2:22][O:16][N:15]=[C:3]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)[CH:24]([CH3:26])[CH3:25])([CH3:19])[CH3:18]

Komponenten

Edukt 4

HCID 73122-(Diisopropylamino)ethyl chloride

HCID 24758Sodium hydride

HCID 136762Cyclododecanone, oxime

HCID 6183479Fumarate(1-)

Produkt 1

HCID 132058051-(Diisopropylamino-ethoxyimino)cyclododecane

Versuchsvorschrift

Starting from 2.4 g. (0.1 moles) of sodium hydride, 19.73 g. (0.1 moles) of cyclododecanone oxime and 17.95 g. (0.11 moles) of 1-diisopropylamino-2-chloroethane the title compound is prepared as in Example 1. Yield: 22.1 g. (68.20%); b.p.: 164°-166° C./0.6 torr. Hydrogen fumarate, m.p.: 120°-121° C.

Quellen und Nachweise

ORD-Eintrag: ord-f9fcca4175f547d8959ec27e0912e2f1
Quelldatensatz: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04285942

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