Ammonium Hydroxide → HCID 86737973, compound

Participants

Reaction Steps

The sulfonic acid (750 mg) is converted to the sulfonyl chloride using thionyl chloride/dimethylformamide then reacted without purification with an excess of ammonium hydroxide to give 6-methyl-7,8-methylenedioxy-1-(p-sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine trifluoroacetamide. Alkaline hydrolysis of the acetamide (500 mg) and boron tribromide treatment of the residue in the cold gives the desired 6-methyl-7,8-dihydroxy-1-(p-sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride.

Provenance & Evidence