反应详情

温度

250 °C

A 100 milliliter flask was charged with 18.4 grams (0.10 mole) p-aminodiphenylamine and 10.6 grams (0.102 mole) α-hydroxy isobutyric acid from Example 1. The mixture was heated to 190° C. where dehydration of the amine-acid salt begins. Water was distilled from the mixture as the temperature slowly increased to 250° C. 2.35 milliliters of distillate was collected and the color of the mixture turned from blue-black to clear amber. After cooling the mixture to 190° C., the amber liquid was poured into a crystallizing dish whereupon it immediately crystallized to give 24.0 gram of N-(4-anilinophenyl)-2-hydroxy-isobutyramide (89% yield).

1. distillationWater was distilled from the mixture as the temperature
2. distillation2.35 milliliters of distillate was collected
3. temperatureAfter cooling the mixture to 190° C.
4. additionthe amber liquid was poured into a crystallizing dish whereupon it
5. customimmediately crystallized