Trifluoroacetic acid → HCID 178513911, compound

HRID 895065Notes

Reaction equation

HRID 895065 reaction equation
C([O:5][C:6]([C:8]1[N:13]2[C:14](=[O:28])[CH:15]([NH:16][C:17](=[O:27])[CH2:18][S:19]([CH2:22][C:23]([F:26])([F:25])[F:24])(=[O:21])=[O:20])[C@H:12]2[S:11][CH2:10][C:9]=1[CH:29]([S:35][C:36]1[NH:40][N:39]=[N:38][N:37]=1)[CH2:30][CH2:31][C:32](=[O:34])[NH2:33])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(#N)C>[F:25][C:23]([F:24])([F:26])[CH2:22][S:19]([CH2:18][C:17]([NH:16][CH:15]1[C:14](=[O:28])[N:13]2[C:8]([C:6]([OH:7])=[O:5])=[C:9]([CH:29]([S:35][C:36]3[NH:40][N:39]=[N:38][N:37]=3)[CH2:30][CH2:31][C:32](=[O:34])[NH2:33])[CH2:10][S:11][C@H:12]12)=[O:27])(=[O:20])=[O:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178450677HCID 178450677, compound

Product 1

HCID 178513911HCID 178513911, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The ester is dissolved in acetonitrile and trifluoroacetic acid is added. The solution is stirred for three hours, then evaporated to dryness to give the title compound.

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-34c638165f3e476cafc7bacab751319f
Source dataset
uspto-grants-1981_08
Patent number
US04286089

Reaction notes

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