Boron tribromide → 1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol

HRID 895186Notes

Reaction equation

C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=3)[CH:9]=2)[C:4]=1[F:21].B(Br)(Br)Br>>[F:21][C:4]1[C:5]2[C:10](=[CH:9][C:8]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[CH:7][CH:6]=2)[CH:11]=[CH:12][C:3]=1[OH:2]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 112197812-Methoxy-6-(4-methoxyphenyl)-1-fluoronaphthalene

Product 1

HCID 102146331-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol

Procedure

The title compound was prepared by reacting 2-methoxy-6-(4-methoxyphenyl)-1-fluoronaphthalene (0.250 g, 0.886 mmol) with boron tribromide (2.7 mL of 1 N solution, 2.7 mmol) according to method D to yield 0.13 g (15%) of a white solid: mp 219-224° C.;

Sources & evidence

ORD record: ord-0b43989b4c1648188693b3144c842858
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06914074B2

Reaction notes

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