2-Bromonaphthalene → HCID 22048151, compound

HRID 895192Notes

Reaction equation

HRID 895192 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[F:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>>[F:12][C:13]1[CH:14]=[C:15]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[CH:3]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]

Participants

3

Reactant 2

HCID 113722-BromonaphthaleneHCID 27821943-Fluoro-4-methoxyphenylboronic acid

Product 1

HCID 22048151HCID 22048151, compound

Procedure

The title compound was prepared by reacting 2-bromonaphthalene (0.31 g, 1.50 mmol) with 3-fluoro-4-methoxyphenylboronic acid (0.31 g, 1.80 mmol) according to method A to yield 0.30 g (79%) of a white solid: mp 108-110° C.; 1H NMR (CDCl3): δ (3.96, 3H, s), 7.04-7.10 (1H, m), 7.43-7.52 (4H, m), 7.68 (1H, dd, J=1.81 Hz, J=8.57 Hz), 7.84-7.92 (3H, m), 7.97 (1H, d, J=1.05 Hz).

Sources & evidence

ORD record
ord-e745eed8c8a6497399a9675ab5f8fd19
Source dataset
uspto-grants-2005_07
Patent number
US06914074B2

Reaction notes

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