反应详情

温度

150 °C

To a mixture of 7-methoxy-3,4-dihydronaphthalene-1-carbonitrile (9.95 g, 53.1 mmol) in p-cymene (100 mLs) was added 10% Pd/C (5 g), the reaction mixture was stirred and heated to 150° C. overnight. The mixture was cooled and the catalyst removed by filtering through filter aid. The p-cymene was removed on the rotovap with the vacuum pump, giving a liquid which solidified on standing. The solid was slurried in hexane, filtered and dried to afford a white solid (4.3 g, 44%). A portion was purified further by silica gel (10% ethyl acetate-hexanes) to produce a white solid: mp 77-78° C.;

1. temperatureThe mixture was cooled
2. customthe catalyst removed
3. filtrationby filtering
4. filtrationthrough filter aid
5. customThe p-cymene was removed on the rotovap with the vacuum pump
6. customgiving a liquid which
7. filtrationfiltered
8. customdried