Hydrochloric Acid → HCID 86584393, compound

HRID 895276Notes

Reaction equation

FC(F)(F)C(O)=O.CC(C)(OC([NH:14][CH2:15][CH2:16][S:17][CH2:18][C@@:19]([CH3:24])([C:21]([OH:23])=[O:22])[NH2:20])=O)C.[ClH:26]>>[ClH:26].[NH2:14][CH2:15][CH2:16][S:17][CH2:18][C@@:19]([CH3:24])([C:21]([OH:23])=[O:22])[NH2:20]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 12085904HCID 12085904, compound

Product 1

HCID 86584393HCID 86584393, compound

Procedure

The product of Example-1D, S-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-2-methyl-L-cysteine trifluoroacetate, (5.5 g, 14.0 mmol) was dissolved in 1 N HCl (100 mL) and stirred at room temperature under nitrogen overnight. The solution was removed by freeze-drying to give the title S-(2-aminoethyl)-2-methyl-L-cysteine hydrochloride, 1H NMR (DMSO-d6/D2O) δ 1.43 (s, 3H), 2.72 (m, 2H), 2.85 (d, 1H), 2.95 (t, 2H), 3.07 (d, 1H). m/z [M+H+] 179.

Workup

customThe solution was removed
customby freeze-drying

Sources & evidence

ORD record: ord-1ea0c53f277e4319bbaa7efbdaed9dbf
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06914158B2

Reaction notes

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