Dimethylformamide dimethyl acetal → Methyl 4-(dimethylamino)-3-methyl-2-oxo-3-butenoate

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Reaction Steps

Methyl-2-ketobutyrate (5 g, 43 mmol) was added at ambient temperature to dimethylformamide dimethyl acetal (5.13 g, 43 mmol, 5.72 ml). The solution was stirred overnight under nitrogen and then the volatile components were removed in vacuo at 40° C. The yellow residue was used without further purification.

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